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KMID : 0191120230380330260
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Journal of Korean Medical Science
2023 Volume.38 No. 33 p.260 ~ p.260
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Circulating Vitamin D Level and Risk of Sudden Cardiac Death and Cardiovascular Mortality: A Dose-Response Meta-Analysis of Prospective Studies
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Kong So-Yeon
Jung Eu-Jene
Cody Chivers
Ro Young-Sun
Shin Sang-Do
Cha Kyoung-Chul
Hwang Sung-Oh
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Abstract
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Background : We conducted a comprehensive meta-analysis of prospective cohort studies to analyze the effect of circulating vitamin D level on the risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality.
Methods : Prospective cohort studies evaluating the association between circulating vitamin D and risk of SCD and CVD mortality were systematically searched in the PubMed and Embase. Extracted data were analyzed using a random effects model and results were expressed in terms of hazard ratio (HR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to estimate the dose-response relationships.
Results : Of the 1,321 records identified using the search strategy, a total of 19 cohort studies were included in the final meta-analysis. The pooled estimate of HR (95% CI) for low vs. high circulating vitamin D level was 1.75 (1.49?2.06) with I2 value of 30.4%. In subgroup analysis, strong effects of circulating vitamin D were observed in healthy general population (pooled HR, 1.84; 95% CI, 1.43?2.38) and the clinical endpoint of SCD (pooled HRs, 2.68; 95% CI, 1.48?4.83). The dose-response analysis at the reference level of < 50 nmol/L showed a significant negative association between circulating vitamin D and risk of SCD and CVD mortality.
Conclusion : Our meta-analysis of prospective cohort studies showed that lower circulating vitamin D level significantly increased the risk of SCD and CVD mortality.
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KEYWORD
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Vitamin D, Death, Sudden, Cardiac, Cardiovascular Disease, Meta-Analysis
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